Glymphatic System Dysfunction in Central Nervous System Diseases - PubMed
3 days ago
- #glymphatic-system
- #CNS-diseases
- #neurodegeneration
- The glymphatic system is a CSF-ISF exchange pathway crucial for brain homeostasis by clearing metabolic waste and neurotoxic proteins.
- Glymphatic dysfunction is linked to various CNS diseases, including acute brain injuries (stroke, TBI) and chronic disorders (Alzheimer's, Parkinson's, etc.).
- Key mechanisms of dysfunction include AQP4 mislocalization, perivascular space obstruction, vascular stiffening, BBB disruption, and sleep dysregulation.
- Clinical assessment of glymphatic function uses imaging techniques like DTI-ALPS and MRI, with links to cognitive and disease severity outcomes.
- Potential therapeutic strategies focus on sleep optimization, vascular risk control, anti-inflammatory approaches, and neuromodulation.