Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial - PubMed
5 hours ago
- #sirolimus
- #aging
- #exercise
- The RAPA-EX-01 trial investigated whether weekly sirolimus (rapamycin) enhances exercise benefits in older adults.
- 40 sedentary adults aged 65–85 performed home-based exercise and received sirolimus 6 mg or placebo weekly for 13 weeks.
- Primary outcome: change in 30-second chair-stand repetitions showed no significant enhancement with sirolimus in intention-to-treat analysis.
- Sensitivity analyses (complete-case and per-protocol) indicated sirolimus may modestly attenuate functional gains compared to placebo.
- Secondary functional outcomes (6-minute walk distance, grip strength) favored placebo but were not statistically significant.
- Adverse events were more frequent with sirolimus (99 vs. 63 events), including one serious case of pneumonia possibly drug-related.
- Conclusion: Weekly sirolimus did not enhance exercise adaptation and may reduce short-term functional improvements while increasing adverse events.