Soluble cytokines and chemokines in NSCLC: drivers of immune evasion and angiogenesis - PubMed
5 hours ago
- #Immunotherapy
- #NSCLC
- #Cytokines
- Soluble cytokines and chemokines in the tumor microenvironment drive immune evasion, angiogenesis, and metastasis in NSCLC.
- Key mediators include IL-6, IL-8, IL-10, CXCL12-CXCR4, CCL21-CCR7, VEGF, bFGF, and MMPs, which modulate immune cell recruitment, EMT, and vascular remodeling.
- Cytokine signatures in blood serve as prognostic biomarkers and predictors for immunotherapy efficacy, offering opportunities for biomarker-guided precision therapy in NSCLC.