TIGAR regulates intestinal mucus barrier integrity by inhibiting lactylation of G6PD/6PGD in ulcerative colitis - PubMed
4 hours ago
- #TIGAR
- #mucus barrier
- #ulcerative colitis
- TIGAR regulates intestinal mucus barrier integrity by inhibiting lactylation of G6PD/6PGD in ulcerative colitis (UC).
- TIGAR promotes NADPH synthesis, mitigating oxidative stress in goblet cells, crucial for UC pathogenesis.
- Low TIGAR expression in UC mice increases lactate levels, leading to G6PD and 6PGD lactylation, impairing their function.
- Impaired G6PD and 6PGD function reduces NADPH synthesis, exacerbating oxidative stress in goblet cells.
- Decline in Trx1 reductase activity causes S-nitrosylation of AGR2, inhibiting MUC2 production and compromising the mucus barrier.
- TIGAR's role in maintaining redox homeostasis presents it as a potential therapeutic target for UC.