Cytoplasmic tail diversity determines the effector bias of the adhesion GPCR ADGRL2 - PubMed
4 days ago
- #signaling bias
- #GPCR
- #arrestin
- The cytoplasmic tail diversity of adhesion GPCR ADGRL2 influences its effector bias.
- The C-terminal tail of ADGRL2 is essential for G protein activation and arrestin-3 recruitment.
- ADGRL2 can recruit arrestin-3 independently of G protein activation, indicating arrestin-3-biased signaling.
- Alternative splicing of the ADGRL2 tail independently modulates G protein activation and arrestin-3 binding.
- GRKs play a role in arrestin-3 recruitment to ADGRL2 but are not strictly essential.
- GRK2 enhances arrestin-3 recruitment only in certain ADGRL2 variants.
- Class B2 aGPCRs interact with arrestin differently than class A GPCRs.
- ADGRL2 splicing determines its effector bias.