Evolutionary dynamics and global spread of macrolide-resistant Bordetella pertussis during the post-pandemic pertussis resurgence - PubMed
3 days ago
- #macrolide-resistant
- #genomic surveillance
- #Bordetella pertussis
- Global resurgence of pertussis post-COVID-19 pandemic investigated through genomic evolution of Bordetella pertussis.
- Analysis of 8,117 B. pertussis genomes from 35 countries, including 249 new isolates from China.
- Emergence and dominance of macrolide-resistant MR-MT28 sublineage in eastern China and its spread globally.
- Parallel antigenic shifts observed with declining PRN-deficient strains and increasing prn2 allele frequencies.
- Region-specific dynamics: China saw near-complete strain replacement by MR-MT28, while Europe and the US saw expansion of local lineages.
- MR-MT28 sublineage has diversified into multiple phylogenetic groups, with 72% of isolates outside China being PRN-deficient.
- Need for coordinated global genomic surveillance highlighted due to public health concerns.