Structure-guided design of a PfCyRPA-based vaccine against blood-stage malaria - PubMed
6 hours ago
- #structure-guided-design
- #PfCyRPA
- #malaria-vaccine
- Effective vaccines against malaria are urgently needed.
- PfCyRPA is a potential vaccine immunogen against blood-stage malaria.
- PfCyRPA is a six-bladed β-propeller with blades 1 and 2 containing epitopes for growth-inhibitory antibodies.
- Structure-guided design created PfCyRPA-EM, a thermostable epitope mimic of blades 1 and 2.
- PfCyRPA-EM elicited more potent growth-inhibitory antibodies than PfCyRPA in pre-clinical models.
- PfCyRPA-EM has higher thermostability and improved expression as an I53-50 nanoparticle fusion.
- PfCyRPA-EM is suitable for clinical development, either alone or with other immunogens.