Aucan targets CDK2 to suppress glioblastoma progression by inhibiting PI3K/AKT pathway-mediated proliferation and inducing apoptosis - PubMed
5 hours ago
- #Glioblastoma
- #CDK2
- #Aucan
- Aucan (C18H17NO6), a dibenzofuran analog from Usnea, shows anti-glioblastoma activity.
- Aucan inhibits glioma cell proliferation, migration, and invasion in vitro.
- In vivo studies show Aucan reduces tumor growth and prolongs survival in mouse models.
- Aucan targets CDK2, suppressing PI3K/AKT pathway-mediated proliferation and inducing apoptosis.
- CDK2 knockdown mimics Aucan's effects, confirming its role in anti-glioma activity.
- Aucan is identified as a potential therapeutic candidate for glioblastoma.