Celastrol protects against renal tubular injury in early diabetic kidney disease through modulation of NOX2 and ferroptosis - PubMed
5 hours ago
- #Ferroptosis
- #Diabetic Kidney Disease
- #Celastrol
- Celastrol protects against renal tubular injury in early diabetic kidney disease (DKD).
- Ferroptosis, a cell death modality linked to ferrous ion dysregulation, plays a role in DKD pathogenesis.
- Celastrol, derived from Tripterygium wilfordii, has anti-inflammatory and antioxidant properties beneficial for DKD.
- Study shows celastrol reduces iron deposition, lipid peroxide accumulation, and mitochondrial damage in DKD models.
- Celastrol downregulates NOX2 expression, which is elevated in early DKD, mitigating renal injury.
- NOX2 agonist PMA partially reverses celastrol's protective effects, confirming NOX2's role in the mechanism.
- Findings suggest celastrol's potential as a therapeutic agent for early DKD by targeting ferroptosis and NOX2.