TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy - PubMed
3 days ago
- #chemotherapy
- #autophagy
- #pyroptosis
- Autophagy can eliminate GSDME-NT on membranes to suppress pyroptosis.
- GSDME-NT on the plasma membrane is removed via endocytic internalization and degraded by autophagy.
- GSDME-NT pores induce endocytosis, forming leaky vesicles that require autophagy for degradation.
- NEDD4L ubiquitinates GSDME-NT on vesicles, which are recognized by TOLLIP for autophagosome formation.
- Disrupting autophagy or TOLLIP recognition increases pyroptosis, enhancing antitumour immunity and chemotherapy efficacy.