m5C-Modified tRF3b-CysGCA-23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4 - PubMed
6 hours ago
- #epigenetics
- #RNA modification
- #bladder cancer
- m5C-modified tsRNA, m5C-tRF3b-CysGCA-23 (mtRC), is downregulated in bladder cancer (BC) and negatively correlates with malignancy.
- mtRC suppresses BC malignancy by stabilizing RNA-binding motif 4 (RBM4), preventing its ubiquitination.
- RBM4 reduces glycolysis and histone H3 lysine 18 lactylation (H3K18la), inhibiting oncogenes IL1RAP and VASH2.
- NSUN6 regulates mtRC abundance and suppresses BC cell proliferation.
- The mtRC/RBM4/H3K18la/IL1RAP&VASH2 axis is a novel regulatory pathway in BC malignancy.