Neuropsychiatric Symptom Clusters and Their Association With Brain Structure in Alzheimer Disease - PubMed
5 hours ago
- #Neuropsychiatric Symptoms
- #Alzheimer's Disease
- #Brain Structure
- Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) were studied using the Neuropsychiatric Inventory Questionnaire (NPI-Q).
- Four symptom clusters were identified: hyperactivity, psychosis, neurovegetative, and affective, explaining 62% of variance.
- Hyperactivity cluster was associated with left middle temporal and right nucleus accumbens volumes.
- Neurovegetative cluster showed associations with left middle temporal and right nucleus accumbens volumes.
- Affective cluster had strong associations with left rostral anterior cingulate and right medial orbitofrontal cortex volumes.
- All clusters predicted instrumental activities of daily living (iADL) outcomes; hyperactivity, neurovegetative, and affective clusters also predicted ADL outcomes.
- Greater NPS burden, male sex, age, lower cognitive scores, and later visits predicted worse functional outcomes.
- The study supports a cluster-based approach linking behavioral symptoms with brain structure and functional decline in AD.