eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression - PubMed
2 hours ago
- #pancreatic cancer
- #metastasis
- #translational control
- eIF4G2 acts as a translational checkpoint that inhibits pancreatic ductal adenocarcinoma (PDAC) progression by regulating mRNA translation.
- Loss of eIF4G2 accelerates tumor growth, leads to poorly differentiated basal-like histology, and triggers widespread metastasis.
- eIF4G2 supports translation of specific mRNAs, including tumor suppressors like Pten and regulators like Crebbp, which have structured 5' UTRs.
- eIF4G2 expression is reduced in poorly differentiated human PDAC lesions, and its perturbation affects clonogenic growth.
- Computational analysis links reduced eIF4G2 activity to increased metastasis, basal-like features, and poorer survival in PDAC patients.