A disease model resource reveals core principles of tissue-specific cancer evolution - PubMed
5 hours ago
- #tissue-specific
- #cancer evolution
- #KRAS
- The study introduces the Mouse Cancer Cell line Atlas (MCCA), a resource with 590 characterized models to explore tissue-specific cancer evolution.
- Key findings include the role of mutant KRAS dosage gain through allelic imbalance in defining cancer initiation timing, especially in pancreatic cancer.
- Tissue- and stage-specific evolutionary requirements, like differentiation block in the intestine, influence KRAS-collaborating alterations.
- Context-dependent KRAS-tumor suppressor interactions explain patterns of cancer gene alterations, including frequency, zygosity, and acquisition order.
- The research provides insights into predictable molecular patterns and temporal dynamics in cancer evolution across different tissues.