The Mediating Factor of Immune Cell in the Causal Relationship Between Cardiovascular Disease-Related Plasma Proteins and Parkinson's Disease: A Network Mendelian Randomization Analysis - PubMed
2 days ago
- #Parkinson's disease
- #Mendelian randomization
- #Cardiovascular disease
- Study investigates the causal relationship between cardiovascular disease (CVD)-related plasma proteins and Parkinson's disease (PD).
- Elevated levels of Fas cell surface death receptors and nerve growth factor reduce PD risk, while thrombomodulin increases PD risk.
- Four immune cell phenotypes mediate the association between CVD-related proteins and PD pathogenesis.
- Mendelian randomization (MR) and bioinformatics methods were used for analysis.
- Results suggest a robust genetic link between CVD-related plasma proteins and PD, mediated by immune cells.