Lipid nanoparticle composition directs systemic trafficking and tissue-specific T cell immunity after intramuscular injection - PubMed
5 hours ago
- #vaccine trafficking
- #tissue-resident T cells
- #lipid nanoparticles
- Lipid nanoparticle composition determines how mRNA-LNP vaccines spread after intramuscular injection.
- Different LNP formulations show varied trafficking: some stay locally, others enter bloodstream and accumulate in organs like liver or lungs.
- Organ-specific accumulation leads to localized antigen expression and cytotoxic T cell responses in those tissues.
- LNPs reaching the liver more efficiently enhanced liver-resident T cell immunity and improved liver tumor control in mice.
- Tuning lipid composition can direct systemic trafficking for designing vaccines with durable, tissue-specific protection.