Distinct TRAPP complexes activate Ypt/Rab GTPases in secretion and autophagy - PubMed
2 days ago
- #Ypt/Rab GTPases
- #TRAPP complexes
- #autophagy
- Ypt/Rab GTPases regulate intracellular transport pathways in yeast and human cells.
- TRAPP complexes activate Ypt/Rab GTPases, with specific roles in secretion and autophagy.
- TRAPPI activates Ypt1 in early-Golgi for early secretion steps.
- TRAPPII activates Ypt31 in late-Golgi for late secretion steps.
- TRAPPIII is implicated in Ypt1 activation specifically in autophagy, not in Golgi transport.
- The distinct roles of TRAPP complexes provide a mechanism for Ypt1/Rab1's dual function in secretion and autophagy.
- Rab1's involvement in autophagy has implications for disease.