Inflammatory protein profiling in immune cells identifies molecular signatures for enhanced diagnostic precision in psoriatic arthritis - PubMed
7 hours ago
- #Biomarkers
- #Psoriatic Arthritis
- #Proteomics
- Study identifies protein signatures in immune cells for improved diagnosis of psoriatic arthritis (PsA).
- Proteomic profiling of 384 inflammation-related proteins in PBMCs was conducted using Olink technology.
- A diagnostic model integrating proteomic and clinical variables showed high accuracy across multiple cohorts.
- Sixty-eight proteins were significantly dysregulated in PsA, indicating immune-inflammatory pathway activation.
- Functional in vitro assays supported the mechanistic relevance of key biomarkers like LILRB4, ADGRE2, and SIGLEC10.
- Distinct proteomic signatures were found between early and established PsA, suggesting molecular patterns linked to disease progression.