Klotho-derived peptide preserves erectile function by limiting fibrosis, oxidative stress, and apoptosis of penile smooth muscle cells in cavernous nerve injured-rats through suppression of the TGF-β1
8 hours ago
- #Klotho peptide
- #TGF-β signaling
- #Erectile dysfunction
- Klotho-derived peptide (KP) improves erectile function in cavernous nerve injured rats by reducing fibrosis, oxidative stress, and apoptosis in penile smooth muscle cells.
- KP works by suppressing TGF-β1/TGF-β type II receptor signaling, which rebalances Smad2/JNK activation and PI3K/AKT suppression.
- The study suggests KP has potential as a therapy for neurogenic erectile dysfunction, especially after radical prostatectomy.