Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism - PubMed

5 hours ago

Camizestrant, a next-generation selective estrogen receptor degrader and antagonist, causes a reversible, dose- and time-dependent reduction in heart rate in clinical and nonclinical studies.
In dogs and rats, camizestrant administration led to significant heart rate reductions, which persisted even after blocking sympathetic and parasympathetic nervous system inputs, indicating a direct cardiac effect.
The mechanism involves inhibition of the hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) and the 'funny' pacemaker current (If) in sinoatrial node cells, reducing pacemaker activity and heart rate.

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