Molecular mechanisms and therapeutic strategies: DNA methylation in pancreatic cancer - PubMed
8 hours ago
- #epigenetic therapy
- #DNA methylation
- #pancreatic cancer
- DNA methylation dysregulation is involved in pancreatic cancer tumorigenesis, affecting invasion, metastasis, therapy resistance, and immune modulation.
- Recurrent patterns include tumor suppressor gene hypermethylation and locus-specific hypomethylation, which drive cancer progression and resistance.
- Methylation-based biomarkers in tissue or cfDNA show potential for early detection and prognostication, though evidence is largely preclinical or retrospective.
- DNA methyltransferase inhibitors, used alone or with immunotherapy/targeted agents, demonstrate preclinical and early clinical efficacy against pancreatic cancer.
- Key challenges include mechanistic gaps, tumor heterogeneity, and assay standardization, requiring further validation for translational impact.