Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A - PubMed
5 hours ago
- #USP13-KDM3A
- #Metastasis
- #Bladder Cancer
- Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis by destabilizing cytoplasmic KDM3A.
- KDM3A, a histone demethylase, is associated with bladder cancer progression and promotes gene transcription by removing H3K9 methylation marks.
- USP13 interacts with KDM3A, removes K63-linked ubiquitin chains, and promotes K48-linked polyubiquitination, leading to KDM3A degradation.
- USP13 is down-regulated in bladder cancer tissues and negatively correlates with KDM3A expression.
- In a bladder cancer metastasis model, USP13 inhibits metastasis by destabilizing KDM3A.
- Targeting the USP13/KDM3A complex could be a therapeutic strategy for bladder cancer.