Metabolite and nutrient regulation of macrophages in obesity and metabolic disease - PubMed
6 hours ago
- #immunometabolism
- #macrophages
- #obesity
- Tissue-resident macrophages sense nutrient fluctuations and help maintain metabolic homeostasis.
- Dysregulated macrophages contribute to obesity-related diseases like type 2 diabetes, fatty liver disease, and cardiovascular disease.
- Obesity leads to macrophage remodelling and low-grade inflammation, causing tissue dysfunction.
- Metabolites like lactate, succinate, and itaconate, along with nutrients such as glucose and fatty acids, regulate macrophage function in metabolic diseases.