Aptamer-functionalized exosomes combined with doxorubicin suppress GBM progression and enhance chemoradiosensitivity by promoting pyroptosis - PubMed
6 hours ago
- #Glioblastoma
- #Pyroptosis
- #Exosomes
- Aptamer-functionalized exosomes (Exo-U2) combined with doxorubicin (DOX) suppress glioblastoma (GBM) progression.
- Exo-U2-Dox complex enhances chemoradiosensitivity by promoting pyroptosis in GBM cells.
- The complex targets EGFRv��, activating NLRP3 inflammasome-mediated pyroptosis, increasing GSDMD and caspase-1 expression.
- Combination therapy with X-rays inhibits 53BP1 expression and reduces ATM/Chk2 pathway phosphorylation, leading to DNA damage accumulation.
- This approach provides a novel targeted therapy for GBM, expanding DOX's therapeutic applications.