Neuropilin-2 Deficiency Promotes Mitochondrial Dysfunction and NAD⁺-Dependent Cellular Senescence in Retinal Degeneration - PubMed
3 days ago
- #retinal degeneration
- #cellular senescence
- #mitochondrial dysfunction
- Neuropilin-2 (NRP2) deficiency in retinal pigment epithelial (RPE) cells leads to mitochondrial dysfunction and NAD+ metabolism disruption.
- NRP2 deficiency causes RPE atrophy, photoreceptor loss, and impaired visual function in mice.
- Mitochondrial elongation, elevated ROS, and reduced NAD+/NADH ratios are observed in NRP2-deficient cells.
- NRP2 loss downregulates SIRT1/SIRT3, increasing protein acetylation and promoting RPE senescence.
- Echinacoside (ECH) treatment rescues mitochondrial dysfunction and reduces senescence markers in vitro and in vivo.
- Targeting the NRP2-mitochondria-NAD+ axis with ECH shows therapeutic potential for retinal degenerative diseases.