Association between the gut microbiota and estimated glomerular filtration rate in two Swedish population-based cohorts - PubMed
4 hours ago
- #Metagenomics
- #Kidney function
- #Gut microbiota
- Study explores gut-kidney interactions in early kidney disease using two Swedish population-based cohorts.
- Deep shotgun metagenomics analyzed fecal samples from 9,788 adults in SCAPIS and 2,080 in MOS.
- 44 bacterial species consistently associated with eGFR, explaining 7% of its variance.
- Histidine and carnitine metabolism pathways were highlighted as significant.
- Key metabolites like trimethylamine N-oxide and imidazole propionate were inversely related to eGFR.
- A metabolite panel accounted for 51% of eGFR variation, indicating microbial metabolic contributions.
- Findings suggest microbial metabolism as a contributor to eGFR variability, offering potential early kidney protection targets.