Acquired resistance of cancer therapies: Mechanisms and perspectives - PubMed
5 hours ago
- #cancer-resistance
- #treatment-challenges
- #therapy-mechanisms
- Significant progress has been made in cancer treatment, including chemotherapy, targeted therapy, and immunotherapy.
- A major challenge is acquired resistance, where patients initially respond but eventually develop resistance and relapse.
- Mechanisms of acquired resistance include tumor cell-intrinsic and extrinsic factors, such as pre-existing resistant clones, genetic mutations, and tumor microenvironment alterations.
- New concepts in resistance include epigenetic alterations, lineage plasticity, metabolic reprogramming, and cellular crosstalk.
- The review aims to provide a theoretical framework integrating emerging resistance concepts and identify actionable therapeutic targets.
- The goal is to develop next-generation combination strategies to prevent or overcome acquired resistance.