Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons - PubMed
5 hours ago
- #Axonal Regeneration
- #Motor Neurons
- #BDNF
- BDNF amplifies neuron-intrinsic programs to enhance axonal regeneration in human iPSC-derived lower motor neurons.
- BDNF temporally regulates expression and RNA stability of regeneration-associated gene sets via metabolic RNA sequencing and phosphoproteomic profiling.
- Regeneration depends on axon-specific activation of the ERK-RSK-S6K kinase pathway in compartmentalized neuron cultures.