Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial - PubMed
21 hours ago
- #clinical trial
- #treatment-resistant depression
- #deep brain stimulation
- Deep brain stimulation (DBS) targeting the BNST-NAc shows efficacy in treatment-resistant depression (TRD).
- Randomized, double-blind crossover trial demonstrates significant reduction in HAMD-17 scores with active vs. sham DBS.
- Open-label stage resulted in a 50% response rate and improvements in anxiety, quality of life, and disability.
- Study identifies optimal stimulation sites, fiber tracts, and functional networks for targeted therapy.
- Serious adverse events included one suicide and one seizure, underscoring need for safety monitoring.