Dissecting Alzheimer's disease heritability across populations - PubMed
5 hours ago
- #Alzheimer's disease
- #heritability
- #genetic epidemiology
- Late-onset Alzheimer's disease (LOAD) heritability was studied across different populations.
- Heritability estimates varied by method, model, and study populations.
- Highest heritability was found in the Dutch isolate (78.3%), followed by non-Hispanic Blacks (39.1%), Dominicans (31.7%), and non-Hispanic Whites (29.1%).
- Adjusting for APOE ε4 reduced heritability estimates by an average of 4.9%.
- SOLAR-Eclipse estimates were generally higher than S.A.G.E. estimates but followed similar trends.
- The study highlights that LOAD heritability is dependent on the study population and may reflect differences in LOAD risk by population.