Crosstalk between SPP1+ macrophages and ITGA5+ fibroblasts promotes hepatocellular carcinoma metastasis - PubMed
5 hours ago
- #Single-cell RNA sequencing
- #Immune microenvironment
- #Hepatocellular carcinoma
- Hepatocellular carcinoma (HCC) progression involves dynamic changes in the immune microenvironment.
- Single-cell RNA sequencing (scRNA-seq) was used to analyze immune microenvironment alterations from healthy liver to HCC.
- SPP1+ macrophages and ITGA5+ fibroblasts interact in HCC, promoting metastasis via MMP2 secretion.
- The SPP1-ITGA5 interaction triggers fibroblast secretion of MMP2, enhancing HCC malignancy.
- Findings provide insights for refining HCC diagnostics and optimizing therapy strategies.