Highly dynamic dural sinuses support meningeal immunity - PubMed
4 days ago
- #meningeal immunity
- #dural sinuses
- #immune surveillance
- Dural sinuses are highly dynamic and support meningeal immunity.
- Dural sinuses undergo RAMP1-dependent constriction and dilation, similar to arterial behavior.
- The superior sagittal sinus in mice is bifurcated into upper and lower chambers, aiding intracranial pressure regulation.
- Specialized, fenestrated sinus endothelial cells (SECs) allow movement of fluids, macromolecules, and microorganisms.
- SECs dynamically regulate intercellular boundaries in a RAMP2-dependent manner for immune surveillance.
- Disruption of SEC dynamics during infection compromises local antiviral immunity and promotes pathogen entry.