Cancer-Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities - PubMed
5 hours ago
- #tumor microenvironment
- #cancer therapy
- #stromal biology
- Cancer-associated fibroblasts (CAFs) are key components in the tumor microenvironment, showing heterogeneity and plasticity from diverse origins.
- CAFs promote cancer through ECM remodeling, immunosuppression, metabolic changes, angiogenesis, therapy resistance, and stem cell maintenance.
- Therapeutic strategies targeting CAFs include depletion, ECM modulation, disrupting cross-talk, with ongoing clinical trials and challenges.
- Future research directions involve single-cell multiomics, patient-derived models, and combinatorial therapies for stroma-targeted treatments.