The Ergogenic Potential of Succinic Acid in Exercise Performance and Post-Exercise Recovery: A Systematic Review - PubMed
4 hours ago
- #systematic-review
- #exercise-performance
- #succinic-acid
- Succinic acid is a key intermediate in the Krebs cycle, playing a central role in human energy metabolism.
- Exercise induces changes in succinate concentrations in skeletal muscle, blood, and saliva, influenced by training status, exercise modality, and intensity.
- This systematic review evaluated the effects of succinate-containing supplements or sole-ingredient succinic acid on exercise performance and post-exercise recovery.
- Six studies involving 153 participants were included, with most rated as having a high risk of bias.
- Three studies reported ergogenic effects, including improvements in maximal oxygen uptake, anaerobic threshold power, and total work performed.
- Two studies showed favorable physiological adaptations like improved acid-base regulation and antioxidant status, though performance outcomes were not directly assessed.
- Current evidence suggests potential benefits, but methodological limitations and high risk of bias in most studies preclude definitive conclusions.
- Well-controlled trials using isolated succinic acid are needed to draw reliable conclusions about its efficacy.