Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization - PubMed
3 days ago
- #colorectal-cancer
- #inflammation
- #Mendelian-randomization
- Study investigates associations between genetically predicted IL-6 and TNF-α signaling pathways and mortality in colorectal cancer (CRC) patients.
- Two-sample Mendelian randomization (MR) analysis used SNPs from GWAS datasets (deCODE and UK Biobank) to predict IL-6 and TNF-α signaling levels.
- Outcome data included CRC-specific mortality from 16,964 CRC cases in the GECCO consortium.
- Genetically predicted sIL6-RA showed a weak positive association with CRC-specific mortality.
- Higher IL6ST levels were associated with increased mortality in stage 2/3 CRC patients.
- No associations were found for TNF-α, sTNF-R1, or sTNF-R2 with CRC mortality.
- Simulation indicated limited collider bias for TNF-α analyses.
- Conclusions suggest IL-6 signaling may have a limited role in CRC progression, while TNF-related pathways appear less relevant for prognosis.