Dietary protein source mediates colitis pathogenesis through bacterial modulation of bile acids - PubMed
4 hours ago
- #Bile Acids
- #Microbiome
- #Inflammatory Bowel Disease
- Red meat protein isolates worsen colitis severity in mice compared to plant-based proteins like pea protein.
- Dietary protein source influences gut microbiota composition, affecting bile acid levels and mucus thickness.
- Beef protein reduces beneficial bacteria like Lactobacillus johnsonii and increases Akkermansia muciniphila, linked to inflammation.
- Taurocholic acid administration exacerbates colitis, indicating bile acid modulation by microbes drives pathogenesis.
- Dietary psyllium fiber counteracts inflammation by restoring microbial balance and normalizing bile acid ratios.