Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis - PubMed
4 days ago
- #MASH
- #Tregs
- #liver health
- Regulatory T cells (Tregs) play a critical protective role in metabolic-dysfunction-associated steatohepatitis (MASH).
- Tregs accumulate in diseased livers, adopting an activated phenotype marked by PPARγ expression and a reparative transcriptional program.
- Ablation of Tregs during MASH leads to severe inflammatory responses, including exaggerated Th1, Th2, and Th17 responses, and hepatocellular injury.
- Treg deficiency disrupts key metabolic pathways in the liver, accelerating disease progression.
- Tregs are essential for maintaining both immunologic and metabolic homeostasis in the liver, making them potential targets for therapies in metabolic liver disease.