Perioperative approaches for patients with biliary tract cancer - PubMed
12 hours ago
- #Perioperative Management
- #Biliary Tract Cancer
- #Oncology
- Biliary tract cancers include intrahepatic, perihilar, distal cholangiocarcinoma, and gallbladder cancer, known for their aggressive nature.
- Most patients present with unresectable disease, and even post-surgery, recurrence is common.
- New treatments include liver transplantation for select patients and combining locoregional with systemic therapies to increase surgical candidacy.
- Immune-checkpoint inhibitors and targeted therapies, initially for advanced-stage disease, are now being explored in earlier stages.
- Treatment strategies are complex, requiring a multidisciplinary and personalized approach.
- Future research aims to optimize patient selection via biomarker-driven strategies and molecular profiling for systemic therapy choices.
- Improving criteria for surgery and transplantation is crucial, necessitating global collaboration and innovative clinical trial designs.