Distinct HIF1α and HIF2α functions control skeletal muscle metabolism and erythropoiesis - PubMed
5 days ago
- #Muscle Biology
- #Hypoxia
- #Metabolism
- HIF1α and HIF2α play distinct roles in skeletal muscle metabolism and erythropoiesis.
- HIF1α increases oxidative fibers but impairs exercise performance and mitochondrial function.
- HIF2α protects against glucose intolerance and diet-induced obesity.
- HIF2α stabilization in skeletal muscle elevates erythropoietin (EPO) levels, identifying muscle as a new EPO production site.
- The study uses mouse models with myofiber-specific PHD knockouts and HIFα overexpression to explore these roles.