p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells - PubMed
6 hours ago
- #cancer biology
- #ZMAT3
- #mitochondrial respiration
- ZMAT3, a p53-induced RNA-binding protein, inhibits transcription of HKDC1 to suppress mitochondrial respiration in cancer cells.
- HKDC1 is identified as the most upregulated protein in ZMAT3-depleted colorectal cancer cells, linking ZMAT3 to glucose metabolism regulation.
- ZMAT3 does not bind directly to HKDC1 RNA or DNA but interacts with the transcription factor JUN to regulate HKDC1 transcription.
- Depletion of ZMAT3 enhances JUN binding to the HKDC1 locus, increasing HKDC1 transcription, which is rescued by JUN depletion.
- The study reveals a novel mechanism where ZMAT3 regulates mitochondrial respiration through JUN-mediated transcriptional control of HKDC1.