Qigui didang decoction alleviates renal injury in a diabetic kidney disease model with metabolic memory features: association with ferroptosis and the SIRT1/Nrf2 pathway - PubMed
5 hours ago
- #Diabetic Kidney Disease
- #Ferroptosis
- #SIRT1/Nrf2 Pathway
- Qigui didang decoction (QGDD) alleviates renal injury in a diabetic kidney disease (DKD) model with metabolic memory features.
- The study explores QGDD's mechanism involving ferroptosis regulation via the SIRT1/Nrf2 signaling pathway.
- QGDD intervention reduced urinary protein excretion and improved renal function markers (BUN, Scr, Cys-C, β2-MG).
- Medium-dose QGDD notably reduced oxidative stress markers (Fe2+, MDA) and increased antioxidant activity (GSH, SOD).
- QGDD activated the SIRT1/Nrf2 pathway, upregulating Nrf2, HO-1, and GPX4 while suppressing AGEs and Ferritin accumulation.
- The medium-dose QGDD group demonstrated optimal therapeutic efficacy, highlighting the importance of dose optimization.
- QGDD's multi-target effects provide a foundation for using Chinese herbal formulations in DKD treatment.