Engineered neuronal exosomes mediate α-synuclein clearance to ameliorate Parkinson's disease - PubMed
3 hours ago
- #Parkinson's Disease
- #Exosomes
- #Neurodegenerative Disorders
- Engineered neuronal exosomes modified for longer blood circulation and enhanced targeting were used to deliver therapies.
- Exosomes were loaded with a peptide to block α-synuclein aggregation and an antioxidant to treat Parkinson's disease.
- Treatment improved motor and cognitive functions in PD model mice by reducing α-synuclein aggregation and enhancing neuroprotection.