Epigenetic regulation of PANoptosis: DNA methylation, histone modifications and non-coding RNAs - PubMed
6 hours ago
- #PANoptosis
- #epigenetics
- #cancer therapy
- PANoptosome multiprotein complexes mediate apoptosis, pyroptosis, and necroptosis convergence.
- Epigenetic regulation (DNA methylation, histone modifications, ncRNAs) controls PANoptotic pathways.
- DNA methylation suppresses PANoptotic genes (RIPK3, GSDME, CASP8), promoting chemoresistance.
- BRD4/p300-mediated histone acetylation (H3K27ac) stimulates ZBP1, NLRP3, and caspase-8 transcription.
- Chromatin remodeling complexes (SWI/SNF, NuRD) regulate PANoptotic gene accessibility.
- ncRNAs (miR-223-3p, lncRNA NEAT1) post-transcriptionally regulate NLRP3, RIPK3, and GSDMD.
- Epigenetic biomarkers combined with DNMTi, HDACi, and PANoptosis agonists may overcome tumor immunoresistance.