Serpina1e mediates the exercise-induced enhancement of hippocampal memory in male mice - PubMed
5 hours ago
- #Serpina1e
- #exercise
- #memory
- Exercise enhances learning and memory through body-brain interactions mediated by secreted factors.
- Intramuscular Serpina1e is upregulated in male mice following exercise.
- Recombinant Serpina1e or intramuscular overexpression replicates exercise-induced memory improvements in sedentary mice.
- Muscle-specific depletion of Serpina1e prevents hippocampal memory enhancement.
- Serpina1e crosses the blood-brain and blood-cerebrospinal fluid barriers to stimulate neurogenesis, BDNF expression, and neurite growth.
- Serpina1e is identified as a key mediator of muscle-brain interactions that enable exercise's cognitive benefits.