Antiviral innate immunity induces alpha synuclein phosphorylation at serine129 in neurons independent of aggregation - PubMed
5 hours ago
- #Alpha synuclein
- #Parkinson's Disease
- #Viral infection
- Alpha synuclein (asyn) is linked to synucleinopathies like Parkinson's Disease.
- Phosphorylation at serine129 (pS129) of asyn is induced by viral infections and increases with aging.
- West Nile Virus (WNV) infection increases pS129 asyn expression in neurons.
- WNV infection, Poly I:C treatment, and type 1 interferon (T1 IFN) treatment induce rapid pS129 asyn formation followed by degradation.
- pS129 asyn induction occurs independently of asyn aggregates.
- Type 1 interferon receptor is essential for pS129 asyn induction.
- Viral infections and antiviral immunity can trigger pS129 asyn formation.
- Further studies on pS129 asyn and interferon signaling may reveal triggers for pathogenic asyn species.