Transfer of IgG from long COVID patients induces symptomology in mice - PubMed
5 hours ago
- #mouse model
- #autoantibodies
- #long COVID
- Transfer of IgG from long COVID patients induces mechanical hypersensitivity in mice.
- Long COVID patients were stratified into three subgroups based on plasma levels of GFAP, NFL, and interferon-β.
- IgG from long COVID patients collected 2 years later reproduced mechanical allodynia in mice, showing longitudinal stability of pathogenic activity.
- Proteome-wide autoantibody profiling identified elevated, subgroup-linked autoreactivities that persist over time.
- Findings support a causal role for autoantibodies in long COVID pathogenesis and suggest a murine model for therapeutic development.