Evolving understandings for the roles of CD38 protein in autoimmunity and autoimmune disease - PubMed
14 hours ago
- #Autoimmunity
- #Inflammation
- #CD38
- Autoimmune diseases are chronic idiopathic disorders characterized by inflammatory responses.
- CD38, a surface molecule with enzymatic and signaling capabilities, regulates NAD+ metabolism and mediates intracellular pathways.
- Recent research highlights CD38's role in autoimmune disease pathogenesis, influencing processes like cell recruitment, activation, and cytokine release.
- Dysfunctional CD38 can induce autoimmune diseases.
- CD38 is expressed at low levels in hematopoietic systems but elevated in multiple myeloma and plasma cells.
- CD38-targeted monoclonal antibodies (e.g., isatuximab, daratumumab, mezagitamab) show therapeutic potential in autoimmune diseases by inhibiting autoantibody production.
- CD38 is a promising biomarker for autoimmune disease diagnosis and a potential therapeutic target.
- The review focuses on CD38's involvement in autoimmunity and its research value in disease control.