The Montreal model of ketamine-therapy for alcohol use disorder and comorbid treatment-resistant depression: protocol for a feasibility trial - PubMed
5 hours ago
- #treatment-resistant-depression
- #alcohol-use-disorder
- #ketamine-therapy
- The Montreal model combines ketamine therapy with acceptance and commitment therapy (ACT) for treating alcohol use disorder and comorbid treatment-resistant depression.
- A feasibility trial will be conducted with 30 participants receiving eight ACT sessions and six ketamine infusions.
- Primary outcomes focus on feasibility, including study completion and protocol adherence.
- Secondary outcomes assess recruitment rate, tolerability, safety, and healthcare resource use.
- Exploratory measures will evaluate changes in depressive symptoms, alcohol use, and quality of life.
- Qualitative interviews with a subset of participants will explore their experiences.
- The study has received ethics approval and results will be published in peer-reviewed journals.