The consensus molecular subtypes of esophageal squamous cell carcinoma - PubMed
2 days ago
- #ESCC
- #molecular subtypes
- #precision medicine
- Esophageal squamous cell carcinoma (ESCC) lacks a standardized classification system, leading to inconsistent clinical management and poor prognosis.
- The study identifies four consensus molecular subtypes (ECMSs): ECMS1-MET (metabolic), ECMS2-CLS (classical), ECMS3-IM (immunomodulatory), and ECMS4-MES (mesenchymal).
- An image-based framework (imECMS) was developed to classify ESCC subtypes using deep learning on H&E-stained whole-slide images.
- The imECMS classifier correlates with molecular characteristics, prognosis, and treatment responses, validated across multiple cohorts.
- The ECMS/imECMS systems provide a robust tool for precision medicine in ESCC, aiding clinical stratification and targeted therapies.