Memantine as a pain management strategy post-total knee arthroplasty: a randomized controlled trial - PubMed
5 hours ago
- #Postoperative Pain
- #Memantine
- #TKA
- Memantine (20 mg pre-op, 10 mg post-op) vs placebo for pain after total knee arthroplasty (TKA).
- No significant difference in pain levels measured by VAS or SF-MPQ between memantine and placebo.
- Memantine significantly reduced opioid use compared to placebo.
- No significant difference in nocturnal awakenings between groups.
- Conclusion: Memantine did not reduce pain but lowered postoperative opioid need.